Search results for "Neuronal development"

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Immature excitatory neurons develop during adolescence in the human amygdala.

2019

The human amygdala grows during childhood, and its abnormal development is linked to mood disorders. The primate amygdala contains a large population of immature neurons in the paralaminar nuclei (PL), suggesting protracted development and possibly neurogenesis. Here we studied human PL development from embryonic stages to adulthood. The PL develops next to the caudal ganglionic eminence, which generates inhibitory interneurons, yet most PL neurons express excitatory markers. In children, most PL cells are immature (DCX+PSA-NCAM+), and during adolescence many transition into mature (TBR1+VGLUT2+) neurons. Immature PL neurons persist into old age, yet local progenitor proliferation sharply d…

0301 basic medicineMaleGeneral Physics and AstronomyHippocampus02 engineering and technologyAdult neurogenesisHippocampusNeural Stem Cellslcsh:ScienceChildPediatricNeuronsMultidisciplinaryNeuronal PlasticitybiologyBasolateral Nuclear ComplexQNeurogenesisMiddle Aged021001 nanoscience & nanotechnologyMental Healthmedicine.anatomical_structureChild PreschoolExcitatory postsynaptic potentialSingle-Cell Analysis0210 nano-technologySequence AnalysisAdultGanglionic eminenceAdolescentScienceNeurogenesisInhibitory postsynaptic potentialAmygdalaArticleGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciencesYoung AdultFetusmedicineHumansPreschoolProgenitorAgedCell NucleusSequence Analysis RNAInfant NewbornNeurosciencesInfantGeneral ChemistryAdolescent DevelopmentStem Cell ResearchNewborn030104 developmental biologynervous systembiology.proteinNeuronal developmentRNAlcsh:QTBR1Neuroscience
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Beyond protein-coding genes

2019

A long non-coding RNA called lnc-NR2F1 regulates several neuronal genes, including some involved in autism and intellectual disabilities.

0301 basic medicineMouseQH301-705.5ScienceautismGenomicsmacromolecular substancesComputational biologyBiologyGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciences0302 clinical medicineIntellectual Disabilitymental disordersgenomicsneuronal developmentmedicineAnimalsHumansAutistic DisorderBiology (General)GeneNeuronsProtein codingRegulation of gene expressionCOUP Transcription Factor Ilong non-coding RNAGeneral Immunology and MicrobiologyGeneral NeuroscienceQRProteinsRNAGenetics and GenomicsGeneral Medicinemedicine.diseaseLong non-coding RNA030104 developmental biologynervous systemNeurodevelopmental DisordersMedicineAutismRNA Long Noncodingintellectual disabilitiesInsightgene regulation030217 neurology & neurosurgeryHumaneLife
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